With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-31-7,1-Ethylpiperazine-2,3-dione,as a common compound, the synthetic route is as follows.
To N-ethyl-2,3-dioxopiperazine (2.84 g, 20 mmol) in DMF (25 mL) at RT under Argon atmosphere was added NaH (60%, 1.07 g, 26.6 mmol) in 3 portions. The reaction mixture was stirred at RT for 30 min, then tert-butyl bromoacetate (4.14 mL, 28 mmol) was added dropwise. The reaction mixture was stirred at RT for 3 h, quenched with aqueous saturated NH4C1, extracted with EtOAc. The organic extracts were combined, washed with water and brine, dried over Na2S04, concentrated, and purified by flash chromatography on silica gel (hexane-acetone,4: 1-0: 100) to afford the product, 940mg. ESI-MS m/z 257 (MH)+.
59702-31-7, As the paragraph descriping shows that 59702-31-7 is playing an increasingly important role.
Reference£º
Patent; VENATORX PHARMACEUTICALS, INC.; BURNS, Christopher J.; DAIGLE, Denis; CHU, Guo-Hua; HAMRICK, Jodie; LUCAS, Matthew; BOYD, Steven A.; ZULLI, Allison L.; MESAROS, Eugen F.; CONDON, Stephen M.; TROUT, Robert E. Lee; MYERS, Cullen L.; (186 pag.)WO2018/218190; (2018); A1;,
Piperazine – Wikipedia
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