With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138775-02-7,(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
(2R)-4-[(benzyloxy)carbonyl]-1 -[(ie f-butoxy)carbonyl]piperazine-2-carboxylic acid (4.00 g, 1 1 .0 mmol), DIPEA (5.1 mL, 27.4 mmol), HATU (5.01 g, 13.2 mmol) and Nu,Omicron- dimethylhydroxylamine hydrochloride (1.29 g, 13.2 mmol) in DMA (40 mL) are stirred at RT for 3 days. The reaction mixture is diluted with EtOAc, washed with water and brine. The organic layer is dried over MgS04, filtered and concentrated under reduced pressure. The residue is purified by silica gel column chromatography to give the title compound. (0523) Yield: 4.44 g (99%) ESI-MS: m/z = 408 (M+H)+
138775-02-7, As the paragraph descriping shows that 138775-02-7 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; SMITH KEENAN, Lana Louise; LOWE, Michael D.; RAZAVI, Hossein; SARKO, Christopher Ronald; SURPRENANT, Simon; TAKAHASHI, Hidenori; TURNER, Michael Robert; WU, Xinyuan; (182 pag.)WO2019/81637; (2019); A1;,
Piperazine – Wikipedia
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