With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: The startingcompound 3-(cyanoacetyl)indole was prepared according tothe procedure described by Slatt et al. [66].A mixture of 3-(cyanoacetyl)indole (1mmol) andheteroaryl-aldehydes a-i (1mmol) in ethanol 0.5mL wasirradiated at 300W and 100C for 8-90min, respectively.After completion of the reaction, the mixture was allowedto cool to room temperature and collected by filtration.The solid products were isolated by crystallization of thereaction mixture from ethanol and washed with a coolmixture of hexane/ethanol (7 : 3, 3 ¡Á 4 mL) to give thecorresponding compounds.The solid products obtainedwerepurified by flash column chromatography performed withSilica gel (60-120mesh) and/or recrystallization using amixture of petroleum ether and ethyl acetate (7 : 3 and 6 : 4)or dichloromethane (CH2Cl2) as
197638-83-8, 197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Treuer, Adriana V.; De-La-Torre, Pedro; Gutierrez, Margarita I.; Journal of Chemistry; vol. 2017; (2017);,
Piperazine – Wikipedia
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