With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.
A mixture of 3-bromobiphenyl (300 mg, 1.28 mmol), 1-cyclopentylpiperazine (238 mg, 1.54 mmol), sodium tert.-butoxide (173 mg, 1.8 mmol), tris(dibenzylideneacetone)dipalladium (12 mg, 0.01 mmol) and racemic 2,2′-bis(diphenylphosphino)-1,1’binaphthyl (24 mg, 0.04 mmol) in toluene (11 ml) was mixed under nitrogen in a closed reaction vessel. The reaction mixture was stirred at 80 C. for 3 days in a closed reaction vessel. It was cooled to room temperature and washed with water (2¡Á10 ml). The combined organic layers were extracted with 1 N hydrochloric acid (2¡Á20 ml). The combined aqueous extracts were made basic with an 1 N aqueous sodium hydroxide solution and extracted with tert-butyl methyl ether (3¡Á20 ml). The tert-butyl methyl ether layers were dried over magnesium sulphate. The solvent was removed in vacuo to give 220 mg of the title compound. [0919] 1H-NMR (CDCl3, two sets of signals, broad signals) delta1.35-1.85 (m, 6 H); 1.95 (m, 2 H); 2.55 (m, 1 H); 2.70 (m, 4 H); 3.30 (m, 4 H); 6.95 (d, 1 H); 7.05 (d, 1 H); 7.15 (s, 1 H); 7.35 (t, 2 H); 7.45 (t, 2 H); 7.60 (d, 2 H). HPLC method B: elution at 10.45 min. [0920] The title compound was transferred into its hydrochloride salt, by dissolving it in ethyl acetate (5 ml). A 3.2 M solution of hydrogen chloride in ethyl acetate (5 ml) was added. The solvent was removed in vacuo. The residue was dissolved in ethanol (50 ml). The solvent was removed in vacuo., 21043-40-3
21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Hohlweg, Rolf; Dorwald, Florencio Zaragoza; Stephensen, Henrik; Pettersson, Ingrid; Peschke, Bernd; US2003/236259; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics