With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.325145-35-5,(S)-tert-Butyl 2-ethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Boc-2-S-ethyl piperazine 22 (prepared as per Kiley et al Org. Prep. Proc- Int. 1990, 22, 761 ; 4.2 g, 18.6 mmol), tris(dibenzylideneacetone)dipalladium (340 mg, 0.37 mmol), racemic-2,2′-bis(diphenylphosphino)-1 ,1′-binaphthyl (BINAP) (495 mtf, 0.74 mmol), cesium carbonate (12 g, 37.2 mmol) and toluene (80 ml). After the mixture was heated at 100 0C for 16 h, fresh tris(dibenzylideneacetone)- dipalladium (340 mg, 0.37 mmol) and BINAP (495 mg, 0.74 mmol) were added and the heating was continued for 3 days. The solvent was removed in vacuo, and the residue was suspended in a 100 ml portion of ethyl acetate. This mixture was extracted with water and brine. The separated organic layer was dried over sodium sulfate and concentrated in vacuo. Purification of the residue via silica gel flash chromatography (5percent methanol/ 95percent DCM) yielded 5.3 g of a partially purified material 23 which was used directly in the next step. M.S. M+H = 350
325145-35-5, As the paragraph descriping shows that 325145-35-5 is playing an increasingly important role.
Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA, INC.; WO2007/109238; (2007); A1;,
Piperazine – Wikipedia
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