With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.
5-(4-Fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione 17 (3.5 mmol, 1.2 eq) with appropriate piperazine derivative (3.0 mmol, 1.0 eq) in 50 mL flat-bottom flask were irradiated in household microwave: 300 MW (1 min), 450 MW (1 min), 300 MW (2 min). Progress of reaction was controlled by TLC (DCM/MeOH 95:5). Pure products were obtained from crude glue-reactants after microwave reaction by: crystallization from methanol (Method A), column chromatography with DCM/MeOH (98:2) as eluent (Method B) and/or dissolving in ethanol and saturating with gaseous HCl to provide product in form of hydrochloride (Method C)., 115761-79-0
As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.
Reference£º
Article; Kucwaj-Brysz, Katarzyna; Warszycki, Dawid; Podlewska, Sabina; Witek, Jagna; Witek, Karolina; Izquierdo, Andrea Gonzalez; Sata?a, Grzegorz; Loza, Maria I.; Lubelska, Annamaria; Latacz, Gniewomir; Bojarski, Andrzej J.; Castro, Marian; Kie?-Kononowicz, Katarzyna; Handzlik, Jadwiga; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 258 – 269;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics