154590-35-9, tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 3-fluoro-4- (N-t-butoxycarbonylpiperazin-1-yl) aniline (16.8 g, 57 mmol) (obtained according to the procedure described in preparation 3) in THF (30 ml), dimethyl aniline (7.92 ml, 62. 7 mmol) was added. To this benzyl chloroformate (8.27 ml, 58. 14 mmol) dissolved in THF (20 ml) was added over a period of 20 min upon stirring at 0 C. After completion of the reaction, the resulting mixture was quenched with saturated NaCl solution (50 ml) and extracted with EtOAc (3 x 200 ml). The organic layer was evaporated, dried over Na2S04 and purified using silica gel column using 50% EtOAc in hexane to afford the title compound (24 g).
154590-35-9, 154590-35-9 tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 16203630, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Orchid Chemicals & Pharmaceuticals Ltd; WO2004/18439; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics