With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1214196-85-6,1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of 1 g rac-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (9, 4.3 mmoles) in 20 mL of anhydrous N,N-dimethylformamide was added 1.7g (12.3 mmoles) of granular potassium carbonate. The slurry wasstirred for 1 hour, and then 1.3 mL (11 mmoles) of benzyl bromide was added and the mixture stirred for an additional 40 hours at room temperature. The reaction mixture was then diluted with water and extracted with ethyl ether. The organic layer was separated and washed with brine (NaCl(aq.)) solution twice. The organic layer was then dried over anhydrous sodium sulfate. Filtration, solvent removal and column chromatography (Hexanes:Ethylacetate gradient) gave 1.49 g of a clear viscous oil (83% yield), which solidified upon standing.
1214196-85-6, The synthetic route of 1214196-85-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Zhao, Huanyu; Prosser, Anthony R.; Liotta, Dennis C.; Wilson, Lawrence J.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 21; (2015); p. 4950 – 4955;,
Piperazine – Wikipedia
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