With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112257-12-2,tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
The 4-(2-bromo acetyl)-piperazine-1-carboxylic acid tert butyl ester (2.0 g, 6.5 mmol, 1 eq) was added to a stirred solution of N-[(5S)-{3-(3-fluoro-4-hydroxy-phenyl)}-2-oxo-oxazolidin-5-ylmethyl]-acetamide (step 4, example 1) (1.75 g, 6.5 mmol, 1 eq) and potassium carbonate (1.138 g, 9.75 mmol, 1.5 eq) in DMF (32 ml). The resulting mixture was heated to 80 C. and stirred for 30 min, then cooled and dichloromethane/methanol (100 ml, 9/1) added. The organic layer was then washed with water (2*10 ml) and saturated sodium chloride solution, and then dried over MgSO4. This was then filtered and the solvent is evaporated. The residue was purified by chromatography (dichloromethane/methanol 9/1) to give the product (1.72 g, 55%) as a brown solid.
112257-12-2, As the paragraph descriping shows that 112257-12-2 is playing an increasingly important role.
Reference£º
Patent; Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie; Hubschwerlen, Christian; Specklin, Jean-Luc; Baeschlin, Daniel; Schmitt, Christine; Mueller, Stefan; Cappi, Michael W.; US9133213; (2015); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics