170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
tert -Butyl 4-(4-Phenoxycarbonylaminophenyl)piperazine-1-carboxylate (XIX; X=H): To a solution of tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (50 g, 0.18 mol) and triethylamine (39 ml, 0.27 mol) in dichloromethane (400 ml) was added dropwise a solution of phenyl chloroformate (36.65 g, 0.23 mol) in dichloromethane (100 ml) at 0 oC. The resulting reaction mixture was stirred for 2 h at 0 C and additional 3 h at room temperature. Then diluted with chloroform (100 ml), washed with water, brine and dried over sodium sulphate. The solvent was removed under reduced pressure, the crude product was purified on a column of silica gel (hexane/EtOAc, 1:1) to give the tiltle compound as colorless solid (60 g, 84%). m.p.: 158-160 C. 1H NMR (CDCl3) delta: 1.48 (s, 9H, 3XCH3), 3.0-3.2 (m, 4H, 2XCH2), 3.6 (m, 4H, 2XCH2), 6.8 (brs, 1H, NH), 6.92 (d, 2H, Ar-H), 7.1-7.5 (complex, 7H, Ar-H).
170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Naeja Pharmaceutical Inc.; TAIHO PHARMACEUTICAL CO., LTD.; EP889881; (2003); B1;,
Piperazine – Wikipedia
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