162046-66-4, 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a suspension of carboxylic acid 17b (3.5 g, 11.4 mmol) in THF (15 mL)containing a drop of DMF was added 1?1?-carbonyldiimidazole (1.24 g, 13.7mmol) in a single portion. The mixture was left to stir at room temperature for 18hours. A stock solution of free-base guanidine was prepared as follows:Guanidine HCl (3.22 g, 34.2 mmol) was added to an aqueous NaOH solution (2M, 10 mL). The THF solution of the acyl imidazole was then added to the freebaseguanidine solution (10 mL) and stirred for 2 hours after which TLC indicatedcomplete consumption of the acyl imidazole and a more polar spot was observedon TLC. Spot stayed on the TLC baseline when using a solvent system of 10%MeOH in DCM but move to an RF ~of 0.4 when a few drop of 7 N NH3 in MeOHwas added to the TLC solvent. The mixture was concentrated in vacuo resulting in the formation of a pale yellowresidue which was dissolved in EtOAc (35 mL). The organic layer was washedwith water (3 x 25 mL), brine (1 x 30 mL), dried (Na2SO4), filtered, andconcentrated under vacuo to give a pale yellow syrup. The crude product wasfurther purified by flash column chromatography (silica gel, Silica Flash-Silicycle) using an eluent of dichloromethane, 5% MeOH in dichloromethane, and10% MeOH in dichloromethane to give an off-white syrup which was converted tothe hydrochloride salt using 1.25 M HCl in methanol. The methanolic solutionwas concentrated under vacuo to give 16 as a light yellow solid (540 mg, 11%)., 162046-66-4
As the paragraph descriping shows that 162046-66-4 is playing an increasingly important role.
Reference£º
Article; Jalily, Pouria H.; Eldstrom, Jodene; Miller, Scott C.; Kwan, Daniel C.; Tai, Sheldon S.-H.; Chou, Doug; Niikura, Masahiro; Tietjen, Ian; Fedida, David; Molecular Pharmacology; vol. 90; 2; (2016); p. 80 – 95;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics