5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-fluoro-3- quinolinecarbonitrile (200 mg, 0.49 mmol), 3- (4-methyl-piperazin-1-yl) propanol (155 mg, 0.98 mmol) (WO 20047212) and sodium hydride (196 mg, 4.6 mmol) in 5 mL of N, N-dimethylformamide was heated at 125C for 3 hours. The reaction mixture was poured into saturated sodium bicarbonate and stirred for 1 hour. The aqueous solution was extracted with 10% methanol in dichloromethane. The organic layer was washed with brine, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by preparative thin layer chromatography, eluting with 15% methanol in dichloromethane. Trituation with hexane provided 116 mg of 4-[(2, 4- dichloro-5-methoxyphenyl) amino]-6-ethoxy-7- [3- (4-methylpiperazin-1- yl) propoxy] quinoline-3-carbonitrile as a light brown solid, mp 137-138C. MS 542.0 (M-H) – Analysis for C27H31CI2N503-0. 6 H20 Calcd : C, 58.40 ; H, 5.84 ; N, 12. 61. Found: C, 58.31 ; H, 5.71 ; N, 12.43., 5317-33-9
As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.
Reference£º
Patent; WYETH; WO2005/47259; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics