With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-39-4,(S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.
314741-39-4, A solution of 3-iodopicolinic acid 2a (1.8 g, 7.23 mmol), (S)-l-tert-butyl 3-methyl piperazine-1,3- dicarboxylate (1.766 g, 7.23 mmol), HATU (3.02 g, 7.95 mmol), DIEA (5.05 mL, 28.9 mmol) in DCM (100 mL) / Acetonitrile (20 mL) was stirred at r.t. for 12 h. DCM (50 mL) and satd. H4Cl (100 mL) were added. The DCM layer was washed with brine, dried over Na2S04, filtered and concentrated. The reaction was purified by column chromatography and the product was eluted by EtOAc to yield (S)-l-tert-butyl 3-methyl 4-(3-iodopicolinoyl)piperazine-l,3-dicarboxylate 2b.
314741-39-4 (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 1501855, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; RAO, Ashwin, U.; MCKITTRICK, Brian Alexander; LOMBARDO, Matthew; HICKS, Jacqueline, D.; MCCRACKEN, Amy Bittner; CHU, Hong Dong; SO, Sung-Sau; ORTH, Peter; WU, Zhicai; LAN, Ping; DEBENHAM, John, S.; WHITEHEAD, Brent, R.; TAYLOR, Jerry, A.; SUN, Zhongxiang; KATIPALLY, Revathi Reddy; GABLE, Jonathan, E.; DAHLGREN, Markus, K.; BHAT, Sathesh, P.; (104 pag.)WO2018/93695; (2018); A1;,
Piperazine – Wikipedia
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