With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.
Add to the reaction flask(E) -4 – [(2-methoxybenzylidene)Benzyl acetate-2-yl]3-nitrobenzoate (III) (4.47 g, 10 mmol),N- (4-aminophenyl) -N-methyl-2- (4-methylpiperazin-1-yl)Acetamide (IV)(2.88 g, 11 mmol) and 50 mL of dioxane, the temperature was raised to 80-85 C and the reaction was stirred for 2.5 hours.Cooled to room temperature, acid-added acid lithium carbonate (1.1 g) was added, and the mixture was stirred at room temperature for 3 hours.The reaction solution was poured into 150 mL of water to precipitate a solid.The crude product was recrystallized from methanol to give a pale yellow solid (Z) -4 – {[2- (N-methyl-2- (4-methylpiperazin-1-yl)Acetamidanilide) benzylidene]Benzyl acetate-2-yl}3-nitrobenzoate(V) 4.93 g, yield 73.9%.
262368-30-9, As the paragraph descriping shows that 262368-30-9 is playing an increasingly important role.
Reference£º
Patent; Suzhou Mirac Pharma Technology Co.,Ltd; Xu, Xuenong; (7 pag.)CN104262232; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics