With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
To a solution of 2-CHLORO-5-METHANESULFONYL-BENZOIC acid (102mg, 0.43 mmol) in dimethylformamide (20 ml) were successively added TBTU (153mg, 0.48 mmol), N- ETHYLDIISOPROPYLAMINE (0.28 ML, 2.17 mmol) and 1- (4-TRIFLUROMETHYLPHENYL) piperazine (ABCR F07741NB, [30459-17-7], 100 mg, 0.43 mmol). The reaction was then stirred at room temperature for two hours, then concentrated in vacuo and purified by column chromatography (SI02, 50g, heptane/ethylacetate = 0 to 100%), to give the title compound as a colorless gum (170 mg, 0.38 mmol). MS (m/e): 464.3 (M+NH4+, 100%), 30459-17-7
30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/23260; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics