120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a stirring mixture of crude acyl chloride 7 (prepared from acid 17 6 (500mg, 1.5mmol)) in anhydrous 93 chloroform (30ml) a solution of 100 (R)-1-Boc-3-aminopyrrolidine (600mg, 3.4mmol) and 101 pyridine (0.6ml, 7.0mmol) in anhydrous chloroform (10ml) was added. The mixture was refluxed for 5min, diluted with chloroform (20ml), washed with aqueous solution of 102 HCl (0.3M), dried and evaporated. The residue was purified by column chromatography on a silica gel in 103 chloroform-methanol (10:0?10:1). The red solid obtained after evaporation was dissolved in hot chloroform (30ml). 104 Methanesulfonic acid (0.3ml, 4.6mmol) was added, the mixture was stirred overnight and evaporated. The residue was dissolved in boiling 105 water (5ml), filtered, the product was precipitated with acetone-ether mixture (3:1). The red solid was collected by filtration, washed with acetone, Et2O, n-hexane and dried.
120737-78-2, As the paragraph descriping shows that 120737-78-2 is playing an increasingly important role.
Reference£º
Article; Shchekotikhin, Andrey E.; Dezhenkova, Lyubov G.; Luzikov, Yuri N.; Treshalin, Michael I.; Shtil, Alexander A.; Preobrazhenskaya, Maria N.; Tsvetkov, Vladimir B.; Volodina, Yulia L.; Tatarskiy, Victor V.; Kalinina, Anastasia A.; Treshalina, Helen M.; Romanenko, Vladimir I.; Kaluzhny, Dmitry N.; Kubbutat, Michael; Schols, Dominique; Pommier, Yves; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 114 – 129;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics