630125-91-6,630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 4-chloro-3-nitrobenzoic acid (1.0 g, 4.97 mmol) in dichioromethane(10 mL) were added oxalyl chloride (500 jiL, 5.30 mmol) followed by catalytic amount ofDMF and the mixture was stirred at RT for 2 h. The mixture was concentrated under reducedpressure and the residue was dissolved in dichloromethane. The solution was cooled to 0 C;4-((4-ethylpiperazin- 1 -yl)methyl)-3 -(trifluoromethyl)aniline (Intermediate Cl) (1.0 g, 3.30mmol) was added to the reaction mixture followed by DIPEA (1.5 mL, 8.30 mmol). The resultant mixture was stirred overnight at RT. The mixture was diluted with water and extracted twice with ethyl acetate. The combined organic extracts were washed with saturated sodium bicarbonate solution, water and brine. The solution was dried over anhydrous sodiumsulfate, filtered and concentrated. The residue thus obtained was purified by columnchromatography to yield 1.43 g of the desired product. ?H NMR (400 MHz, DMSO-d6) oe0.98 (t, J 7.2 Hz, 3H), 2.28-2.39 (m, 1OH), 3.57 (s, 2H), 7.74 (d, J 8.4 Hz, 1H), 7.98-8.04(m, 2H), 8.16 (s, 1H), 8.27 (dd, J, = 2.4 Hz, J2 = 8.4 Hz, 1H), 8.65 (s, 1H), 10.77 (s, 1H).
The synthetic route of 630125-91-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; PATEL, Vinod; REDDY, Venkateshwar; GHARAT, Laxmikant Atmaram; CHAUDHARI, Sachin Sundarlal; DAS, Sanjib; VELGALETI, Ranganadh; SHAH, Daisy Manish; BAJPAI, Malini; (262 pag.)WO2018/215668; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics