192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A microwave vial was charged with 4-(4-benzylphenylamino)-6-fluoro-1 ,7- naphthyridine-3-carbonitrile (0.100 g, 0.282 mmol), 1-N-BOC-4-(2- aminoethyl)piperazine and 2 mL THF, crimp-sealed, and heated in a microwave reactor at 180 0C for 35 minutes, until TLC analysis (5percent MeOH in CH2CI2) showed disappearance of the 6-fluoronaphthyridine. This process was repeated with 3 additional aliquots of the fluoronaphthyridine (0.12O g, 0.100 g, 0.10O g), and the contents of all 4 vials were then combined, partitioned between 50 mL each EtOAc and brine, and worked up as described above for the synthesis of WAY-191220. The crude product was purified by flash chromatography over silica gel (5percent MeOH in CH2CI2) and lyophilized to give pure 4-(4-benzylphenylamino)-6-(2-(1 -N-BOC- piperazin-4-yl)ethylamino)-1 ,7-naphthyridine-3-carbonitrile (0.151 g, 23percent yield): 1H NMR (400 MHz, DMSO-D6) t 1.39 (s, 9 H) 2.34 – 2.44 (m, 4 H) 2.57 (t, J=6.6 Hz, 2 H) 3.21 – 3.42 (m, 6 H) 3.99 (s, 2 H) 6.59 (t, J=5.3 Hz, 1 H) 7.03 (s, 1 H) 7.14 – 7.34 (m, 9 H) 8.22 (s, 1 H) 8.81 (s, 1 H) 9.56 (s, 1 H)., 192130-34-0
The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; WYETH; WO2006/124944; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics