With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
EXAMPLE 17 3-Methyl-5-[2-[4-[4-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2-oxazolidinone This compound was prepared according to the procedure of Example 2. A mixture of 3.5 g (0.015 mol) of 1-(4-trifluoromethylphenyl)piperazine (Emka-Chemie), 2.5 g (0.015 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 5.3 g (0.05 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol gave 3.7 g (69%) of white solid, mp 116-117 C. (2-propanol). Anal. Calculated for C17 H22 F3 N3 O2: C, 57.14; H, 6.20; N, 11.76. Found: C, 56.74; H, 6.24; N, 11.55., 30459-17-7
The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; A. H. Robins Company, Incorporated; US5086055; (1992); A;,
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