197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.
tert-Butyl4-(4-(6-chloro-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H- imidazo[4,5-?>]pyridin-2-yl)phenyl)piperazine-1-carboxylateTo a mixture of 5-chloro-4-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3- nitropyridin-2-amine (0.100 g, 0.27 mmol, 1 eq), EtOH (4.7 mL) and DMF (0.63 mL), terf-butyl-4-(4-formylphenyl)tetrahydro-1-(2H)pyrazine carboxylate (0.087 g, 0.3 mmol, 1.1 eq) was added followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.82 mL, 0.82 mmol). The reaction mixture was heated at 85C for 24 h, then allowed to cool to room temperature and diluted with DCM and a few drops of aqueous NH3 until complete dissolution was observed. This solution was deposited on two preparative silica TLC plates and eluted with DCM/MeOH (v/v; 94:6). The title compound was obtained after trituration with diethyl ether as an off-white solid (0.050 g, 30%); 1H-NMR (500Mz, DMSO-c/6): delta 1.43 (s, 9H, C(CH3J3), 2.59-2.67 (m, 4H, piperazine N(CH2)2), 3.45-3.52 (m, 4H, piperazine N(CH2J2), 3.66 (s, 2H, NCH2), 3.65-3.74 (m, 4H, piperazine N(CH2)2), missing 4H piperazine N(CH2)2 under solvents peaks, 7.07 (d, J = 9.5 Hz, 2H, ArH, C6H4), 7.64-7.74 (m, 1 H, py 4-H)1 8.01- 8.07 (m, 3H, ArH and imidazo [4,5-]pyridine 5-H), 8.44-8.47 (m, 1 H), 8.49 (d, J = 2.5 Hz, 1H, py 6-H), 13.19 (br s, 1H, imidazo[4,5-b]pyridine N-H); LC (Method B) – MS (ESI, m/z) 4.51 min – 607/609 [(M+H)+, Cl isotopic pattern]; ESI-HRMS: Found: 607.2743, calculated for C31H36CIFN8O2 (M+H)+: 607.2707.
197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.
Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics