55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
55121-99-8, Example No. 131Preparation of 5- (3-methoxyphenyl) -N- (4- ( (4-methylpiperazin-l- yl) methyl) phenyl) -IH-pyrazolo [4 , 3-d] pyrimidin-7-amine7-chloro-2- (4-methoxybenzyl) -5- (3-methoxyphenyl) -2H- pyrazolo [4 , 3 -d] pyrimidine (0.16 mmol) and 4 -Amino-phenyl) – (4 – methyl-piperazin-l-yl) -methanone (0.3 mmol 2 eq. , ) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HCl in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140 C. The reaction mixture was concentrated and dissolved in THF (dry) LiAlH4 powder was added (excess, 2 by 2 eq) until completion of reaction is observed (by LCMS) . The reaction was quenched with water (lmL per gram LiAlH4) , then NaOH (ca. 15% aq. , lmL per g LiAlH ) , water (3mL per gram LiAlH4) . The mixture was filtered, washed with THF, MeOH, MeCN (ca. 10ML each) . The reaction mixture was concentrated and purified by semi-preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 429.27 g/molHPLC-MS: analytical method Art: 2.239 min – found mass: 430 (m/z+H)
The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; TRAUBE, Nadine; WO2012/143144; (2012); A1;,
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