The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
Intermediate B58: 4-[4-(1 -methylethyl)-1 -piperazinyl]-2,5-bis(methyloxy)aniline; Step A/Intermediate B59: 1-[2,5-bis(methyloxy)-4-nitrophenyl]-4-(1- methylethyl)piperazine; 1-chloro-2,5-bis(methyloxy)-4-nitrobenzene (3.25g, 15 mmol, TCI America), isopropylpiperizine (3.84g, 30 mmol, Oakwood Products), cesium carbonate (9.8g, 30 mmol), Pd2dba3 (1.37g, 1.5 mmol), and XANTPHOS (1.3g, 2.25 mmol) were added to degassed dioxane (80 mL) and heated to 1000C under a water cooled reflux condenser for 12 hours. The dioxane was removed under reduced pressure and the solids were partitioned between methylene chloride (500 mL) and water (500 mL). The organic layer was dried over sodium sulfate, taken to a residue under reduced pressure, and purified by chromatography on SiO2 to give 1-[2,5- bis(methyloxy)-4-nitrophenyl]-4-(1-methylethyl)piperazine as a yellow solid (3.5g, 11.3 mmol, 76percent yield). 1 H NMR (400 MHz, CDCI3) delta ppm 1.09 (d, J=6.60 Hz, 6 H), 2.69 – 2.73 (m, 4 H), 2.75 (d, J=6.60 Hz, 1 H), 3.23 – 3.32 (m, 4 H), 3.88 (s, 3 H), 3.94 (s, 3 H), 6.48 (s, 1 H), 7.55 (s, 1 H)., 4318-42-7
The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/20990; (2009); A1;,
Piperazine – Wikipedia
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