With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.474711-89-2,Piperazine-1-carboxamide hydrochloride,as a common compound, the synthetic route is as follows.,474711-89-2
Example 164: Preparation of 4-{4-[(3S)-2,3-dihydro[l,4]dioxino[2,3-b]pyridin-3- yl]benzyl}piperazine-l-carboxamide (164). To a solution of Intermediate C (30.0 g, 124 mmol) in DCM (500 mL) is added 164-1 (26.7 g, 161 mmol) followed by TEA (20.9 mL, 149 mmol). After stirring for 10 min at rt, sodium triacetoxyborohydride (36.0 g, 161 mmol) is added and the mixture stirred at rt for 24 hours. The reaction mixture is washed with sat.NaHCC (2 x 300 mL), and brine (400 mL). The organic layer is dried over Na2S04, filtered and concentrated. The solid is triturated twice in ethyl ether at 65C. After the second filtration, the resultant solid is recrystallized from ethanol to afford the title compound 164. (LC/MS method 11 : ES+ m/z 355.1 [M+H]+, Rt = 0.38 min).
474711-89-2 Piperazine-1-carboxamide hydrochloride 2769700, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRUNETTE, Steven, Richard; ABEYWARDANE, Asitha; BURKE, Michael, J.; KAPADIA, Suresh, R.; KIRRANE, Thomas, Martin, Jr.; NETHERTON, Matthew, Russell; RAZAVI, Hossein; RODRIGUEZ, Sonia; SAHA, Anjan; SIBLEY, Robert; SMITH KEENAN, Lana, Louise; TAKAHASHI, Hidenori; TURNER, Michael, Robert; WU, Jiang-Ping; YOUNG, Erick, Richard, Roush; ZHANG, Qiang; ZHANG, Qing; ZINDELL, Renee, M.; WO2013/134226; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics