13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 18: N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidin e-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide [Show Image] 400 mg (1.07 mmol) N-{[1-(2-hydroxypropyl)-pyrrolidin e-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide and 0.18 ml(1.29 mmol, 1.2 eq.)triethylamine described in manufacturing example 6 were dissolved to 20 ml dichloromethane and cooled to 3C under argon gas. 135 mg (1.18 mmol, 1.1 eq.) methansulfonyl chloride were slowly added to reaction solution and stirred at same temperature for 30 min. 20 ml purified water were added and then the organic layer was separated and concentrated with decompression. After 10 ml acetonitrile were added to obtained residues and dissolved them, 444 mg (3.21 mmol) potassium carbonate and 202 mg (1.06 mmol) 1-benzoylpiperazine were added. After stirring for 2 hours at room temperature, 15 ml saturated sodium chloride aqueous solution were added to the reaction solution and was extracted twice with 15 ml ethylacetate. After the organic layer was collected and dried with anhydrous magnesium sulfate, it was concentrated with decompression. 30 mg (51%) target compound as light-yellow solid were yielded by purifying obtained residues with chromatography using silicagel (mobile phase: dichloromethane/methanol=5:1 and 1:1). 1H NMR(400MHz,DMSO-d6) 1.05(3H,s), 1.55-1.65(1H,m), 2.00-2.10(1H,m), 2.15-2.25(1H,m), 2.28-2.55(9H,m), 2.70-2.85(2H,m), 3.17(1H,d) 3.54-3.65(2H,m), 3.87(2H,d), 4.10-4.20(1H,m) 7.35-7.40(2H,m), 7.40-7.47(3H,m), 7.74(1H,t), 7.92(1H,d), 8.14(1H,s) 8.18(1H,d) 8.23(1H,s), 9.01(1H,t) MS (M)+ 545.6, 13754-38-6
As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.
Reference£º
Patent; Yang Ji Chemical Co., Ltd.; EP2452939; (2012); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics