With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: A mixture of 4-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine 12 (1 g, 4.34 mmol) and 1,4-dioxa-8-azaspiro[4.5]decane (0.62 g, 4.34 mmol) in 2-propanol (30 mL) or 95% ethanol for other amines was refluxed for two hour. The white solid formed in the hot solution was collected after cooling and further recrystallized from ethanol yielded white crystals of compound 13a (67%), 30459-17-7
As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.
Reference£º
Article; Abdelazeem, Ahmed H.; Abdelatef, Shaimaa A.; El-Saadi, Mohammed T.; Omar, Hany A.; Khan, Shabana I.; McCurdy, Christopher R.; El-Moghazy, Samir M.; European Journal of Pharmaceutical Sciences; vol. 62; (2014); p. 197 – 211;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics