With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
129779-30-2, To a solution of tert-butyl czs-3,5-dimethylpiperazine-l-carboxylate (1.80 g, 8.40 mmol) in DCM (20 mL) was added a 37% HCHO solution (0.34 mL, 12.0 mmol) dropwise at 0 C, followed by portion- wise addition of Na(OAc)3BH (2.31 g, 10.9 mmol). The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was diluted with DCM (30 mL) and washed with NaHC03 (20 mL) solution. The organic layer was separated, washed with brine (20 mL), dried over anhydrous Na2S04 and concentrated in vacuo to afford tert-butyl czs-3,4,5- trimethylpiperazine-l-carboxylate (1.81 g crude) as a colorless liquid. This compound was used as such for the next reaction without further purification. LC/MS (ESI) m/e [M+H]+/RT (min)/%: 228.90/4.29/88.5%. 1H NMR (400 MHz, CDC13) delta 1.08 (d, J = 6.1 Hz, 6H), 1.48 (s, 9H), 2.04-2.18 (m, 2H), 2.26 (s, 3H), 2.56-2.62 (m, 2H), 3.78-3.98 (m, 2H).
129779-30-2 (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 10822535, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; HALL, Adrian; MACCOSS, Malcolm; (139 pag.)WO2017/20010; (2017); A1;,
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