With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-39-1,2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.,5521-39-1
Synthesis of //ONo.is-4-(5-Bromo-2-{4-[4-(2- hydroxy-ethyl)-piperazin-l-yl]-phenylamino}-pyrimidin-4-ylamino)adamantan-l-ol:Conc.HCl (20mL) was added to a mixture of tra?s-4-(5-bromo-2-chloropyrirnidin-4- ylamino)adamantan-l-ol (50mg, 139 mmoles) and 2-[4-(4-aminophenyl)piperazin-l- yl]ethanol (37mg, 0.167mmoles) in n-butanol (3ml) was and the mixture was heated at 1 10- 120 overnight. The reaction mixture was cooled to 80, n-butanol (5 ml) was added and filtered. The residue was triturated with hot MeOH, purified by preparative HPLC to afford lOmg of trara-4-(5-Bromo-2-{4-[4-(2-hydroxy-ethyl)-piperazin-l-yl]-phenylamino}- pyrimidin-4-ylamino)adamantan-l-ol inl3% yield.’H NMR (DMSO-d6) delta 10.2-10.35 (br s, H), 9.2-9.3 (br s,lH), 8.1-8.2 (s,lH), 7.5 (d,2H), 7.0 (d,2H)?6.2(s,lH), 3.0-4.0 (m,12H), 2.2-2.3 (s,2H), 2.0-2.1 (s,lH), 1.6-1.8 (m,7H), 1.3-1.5 (m,4H) LC-MS: 543 (M + l)
The synthetic route of 5521-39-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara; WO2012/59932; (2012); A1;,
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