With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
4.1.14 (3-Trifluoromethyl-1-phenyl-1H-pyrazol-5-yl)piperazine (12e) To a solution of 10a (19.0 g, 86.3 mmol) in pyridine (150 mL) was added acetic anhydride (9.0 mL, 95 mmol) at room temperature. The mixture was stirred for 18 h, and then concentrated under reduced pressure. The residue was poured into a 10percent aqueous citric acid solution and extracted with ethyl acetate. The extract was washed with brine, dried and concentrated under reduced pressure to give 4-acetyl-1-benzyloxycarbonylpiperazine (22.6 g, 100percent) as an oil. 1H NMR (300 MHz, DMSO-d6): delta 2.78 (2H, s), 3.35-3.68 (8H, m), 5.10 (2H, s), 7.28-7.42 (5H, m).
31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.
Reference£º
Article; Yoshida, Tomohiro; Akahoshi, Fumihiko; Sakashita, Hiroshi; Kitajima, Hiroshi; Nakamura, Mitsuharu; Sonda, Shuji; Takeuchi, Masahiro; Tanaka, Yoshihito; Ueda, Naoko; Sekiguchi, Sumie; Ishige, Takayuki; Shima, Kyoko; Nabeno, Mika; Abe, Yuji; Anabuki, Jun; Soejima, Aki; Yoshida, Kumiko; Takashina, Yoko; Ishii, Shinichi; Kiuchi, Satoko; Fukuda, Sayaka; Tsutsumiuchi, Reiko; Kosaka, Keigo; Murozono, Takahiro; Nakamaru, Yoshinobu; Utsumi, Hiroyuki; Masutomi, Naoya; Kishida, Hiroyuki; Miyaguchi, Ikuko; Hayashi, Yoshiharu; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5705 – 5719;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics