With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.
Maleic anhydride (501.9 mg, 5.11 mmol) was dissolved in CHC13 (25 mL) and 2-(4- methylpiperazin-l-yl)ethan-l -amine (767 mu^, 5.11 mmol) was then added. The reaction was stirred at room temperature for 2 hours. The solvent was removed in vacuo and the crude solid was resuspended in acetic anhydride (25 mL). To the reaction was then added sodium acetate (250 mg). The reaction was heated to reflux under N2 for 3 hours. After reflux, the reaction was cooled to room temperature and washed with hexanes to obtain 3 (crude) as a dark brown/black oil. MS: m/z (M+l) +: 224.28, 934-98-5
As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.
Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James E.; QI, Jun; FEDERATION, Alexander; JACOBSON, Zoe; VARCA, Anthony; (125 pag.)WO2018/58029; (2018); A1;,
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