With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1030377-21-9,(S)-1-Boc-2-(Hydroxymethyl)piperazine,as a common compound, the synthetic route is as follows.
To (S)-2-hydroxymethylpiperazine-1-carboxylic acid tert-butyl ester (950 mg) were added tetrahydrofuran (17 mL),3,5-dimethylpyridine-N-oxide (515 mg),N,N-diisopropylethylamine (2.8 mL) and bromotris(pyrrolidino)phosphonium hexafluorophosphate (2.67 g) and the mixture was stirred at room temperature for 5.5 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The solvent was evaporated and the obtained residue was purified by column chromatography (ethyl acetate:hexane)to give the title compound (640 mg). MS(ESI)m/z:322 (M+H)+
1030377-21-9, 1030377-21-9 (S)-1-Boc-2-(Hydroxymethyl)piperazine 22884145, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; ISHIBUCHI, Seigo; SARUTA, Kunio; HAMADA, Maiko; MATOBA, Nobuatsu; MATSUDAIRA, Tetsuji; SEKI, Maki; TARAO, Akiko; HONJO, Takashi; OGATA, Shingo; KAWATA, Atsushi; MOROKUMA, Kenji; FUJIE, Naoto; AOYAMA, Yukio; (251 pag.)EP3321256; (2018); A1;,
Piperazine – Wikipedia
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