With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.,122833-04-9
10208] Step 1. To a mixture of 2-methoxy-4-(4-methylpip- erazin-1-yl)aniline (Combi-l3locks mc, Cat: SS-3744; 342 mg, 1.55 mmol) and tert-butyl (3-(2-(methylsulfinyl)-7-ox- opyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate (52) (521 mg, 1.30 mmol)intert-butanol(lOmL, 105 mmol) was added DIEA (0.57 mE, 3.25 mmol). The reactionmixture was heated at 800 C. in an oil bath for 21 h. The resulting brown suspension was concentrated under reduced pressure and the crude solid was suspended in Et20 (ca. 20 mE) and filtered affording the crude material of tert-butyl (3-(2-((2-methoxy- 4-(4-methylpiperazin-1 -yl)phenyl)amino)-7-oxopyrido[2,3- d]pyrimidin-8(7H)-yl)phenyl)carbamate (la) as a green solid. mlz (ESI, +ve ion) 558.0 (M+H). ?H NMR (400 MHz, DMSO-d5) oe ppm 9.57 (1H, s), 8.73 (1H, s), 8.14 (1H, s), 7.89 (1H, d, J9.4 Hz), 7.57 (1H, d, J8.4 Hz), 7.42 (3H, t, J8.0Hz), 7.28 (1H, d, J8.8 Hz), 6.87 (1H, d, J8.6 Hz), 6.53 (1H, d, J2.3 Hz), 6.43 (1H, d, J9.4 Hz), 6.05 (1H, br. s.), 3.73- 3.82 (3H, m), 3.06 (4H, br. s.), 2.36-2.47 (4H, 2.15-2.26 (3H, s), 1.45 (9H, s).
122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; TASKER, Andrew; WURZ, Ryan; PETTUS, Liping H.; HERBERICH, Bradley J.; US2014/249131; (2014); A1;,
Piperazine – Wikipedia
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