With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118753-66-5,tert-Butyl 4-aminopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a stirred solution of tert-butyl 4-aminopiperazine-l-carboxylate (0.200 g, 0.99 mmol, 1.0 equiv) in DMF (05 mL) was added HATU (0.753 g, 1.98 mmol, 2.0 equiv) at RT and stirred for 10 minutes. Then 2-(4-chloro-3-fluorophenoxy)acetic acid (0.201 g, 0.99 mmol, 1.0 equiv) was added followed by the addition of DIPEA (0.6 mL, 2.97 mmol, 3.0 equiv). The resulting reaction mixture was allowed to stir at RT for overnight. Product formation was confirmed by LCMS. The reaction mixture was diluted with water (50 mL) and extracted with EtOAc (50 mL * 2). The combined organic layer was washed with water (30mL), brine solution (30 mL x 2), dried over anhydrous sodium sulfate and concentrated under reduced pressure, to obtain tert-butyl 4-(2-(4-chloro-3-fluorophenoxy)acetamido)piperazine-l -carboxylate (0.150 g, 38 % Yield) as a semi solid. LCMS 388 2 | M H | ; NMR (400MHz, DMSO-de) d 7.57 – 7.36 (m, 1 H), 7.11 – 6.94 (m, 1 H), 6.92 – 6.69 ( m. 1 H), 5.76 (s, 1 H), 5.04 – 4.79 (m, 1 ). 4.48 (s, 1 H), 3.85 (br s, 1 H), 2.92 (br. s., 2 H), 2.70 (d, J= 11.8 Hz, 2 H), 1 40 (s, 9 H)., 118753-66-5
The synthetic route of 118753-66-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PRAXIS BIOTECH LLC; DELGADO OYARZO, Luz Marina; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; (0 pag.)WO2019/236710; (2019); A1;,
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