With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: An ethanolic solution (10 mL) of sodium hydroxide (10 mmol, 0.4 g) was added to an ethanolicsolution (10 mL) of the secondary amine (10 mmol). The mixture was cooled in an ice bath; additionally,carbon disulfide (100 mmol, 6.0 mL) was added dropwise with continuous stirring for 1 h at roomtemperature. The precipitates were filtrated and washed with diethyl ether to obtain a white topale-yellow-colored product in 70-90% yield
103-76-4, 103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Hussein, Weiam; Sa?lik, Beguem Nurpelin; Levent, Serkan; Korkut, Bue?ra; Ilgin, Sinem; Oezkay, Yusuf; Kaplancikli, Zafer Asim; Molecules; vol. 23; 8; (2018);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics