Month: November 2020

55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, Example No. 131Preparation of 5- (3-methoxyphenyl) -N- (4- ( (4-methylpiperazin-l- yl) methyl) phenyl) -IH-pyrazolo [4 , 3-d] pyrimidin-7-amine7-chloro-2- (4-methoxybenzyl) -5- (3-methoxyphenyl) -2H- pyrazolo [4 , 3 -d] pyrimidine (0.16 mmol) and 4 -Amino-phenyl) – (4 – methyl-piperazin-l-yl) -methanone (0.3 mmol 2 eq. , ) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HCl in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140 C. The reaction mixture was concentrated and dissolved in THF (dry) LiAlH4 powder was added (excess, 2 by 2 eq) until completion of reaction is observed (by LCMS) . The reaction was quenched with water (lmL per gram LiAlH4) , then NaOH (ca. 15% aq. , lmL per g LiAlH ) , water (3mL per gram LiAlH4) . The mixture was filtered, washed with THF, MeOH, MeCN (ca. 10ML each) . The reaction mixture was concentrated and purified by semi-preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 429.27 g/molHPLC-MS: analytical method Art: 2.239 min – found mass: 430 (m/z+H)

The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; TRAUBE, Nadine; WO2012/143144; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

53788-49-1, tert-Butyl 4-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,53788-49-1

t-BOC-Protected methylpiperizine was heated in the presence of l-fluoro-4- nitrobenzene under pressure in benzene to give 4-t-BOC-protected 1-methyl-1- (4- nitrophenyl) piperazinium salt. The piperazinium salt was heated in the presence of potassium [F] fluoride and Krytofix at 200C for 10 minutes. The oil was treated with aq. 3 M HC1 for 20 minutes to give [F-18]-1-methyl-1-(4-fluorophenyl) piperazinium chloride

53788-49-1 tert-Butyl 4-methylpiperazine-1-carboxylate 11401394, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; THE GENERAL HOSPITAL CORPORATION; WO2005/82425; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.474711-89-2,Piperazine-1-carboxamide hydrochloride,as a common compound, the synthetic route is as follows.,474711-89-2

Example 164: Preparation of 4-{4-[(3S)-2,3-dihydro[l,4]dioxino[2,3-b]pyridin-3- yl]benzyl}piperazine-l-carboxamide (164). To a solution of Intermediate C (30.0 g, 124 mmol) in DCM (500 mL) is added 164-1 (26.7 g, 161 mmol) followed by TEA (20.9 mL, 149 mmol). After stirring for 10 min at rt, sodium triacetoxyborohydride (36.0 g, 161 mmol) is added and the mixture stirred at rt for 24 hours. The reaction mixture is washed with sat.NaHCC (2 x 300 mL), and brine (400 mL). The organic layer is dried over Na2S04, filtered and concentrated. The solid is triturated twice in ethyl ether at 65C. After the second filtration, the resultant solid is recrystallized from ethanol to afford the title compound 164. (LC/MS method 11 : ES+ m/z 355.1 [M+H]+, Rt = 0.38 min).

474711-89-2 Piperazine-1-carboxamide hydrochloride 2769700, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRUNETTE, Steven, Richard; ABEYWARDANE, Asitha; BURKE, Michael, J.; KAPADIA, Suresh, R.; KIRRANE, Thomas, Martin, Jr.; NETHERTON, Matthew, Russell; RAZAVI, Hossein; RODRIGUEZ, Sonia; SAHA, Anjan; SIBLEY, Robert; SMITH KEENAN, Lana, Louise; TAKAHASHI, Hidenori; TURNER, Michael, Robert; WU, Jiang-Ping; YOUNG, Erick, Richard, Roush; ZHANG, Qiang; ZHANG, Qing; ZINDELL, Renee, M.; WO2013/134226; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 7-bromo-5-chloro-furo[3,2-b]pyridine-2-carboxylic acid (200 mg, 0.723 mmol) and tert-butyl 3,3-dimethylpiperazine-1-carboxylate (164.3 mg, 0.767 mmol) in DMF (2.13 mL) was added N-methyl morpholine (329.2 mg, 357.8 muL, 3.26 mmol) at ambient temperature. T3P (575.4 mg, 0.904 mmol) 50% W/W in DMF was added dropwise and the solution was stirred at room temperature for 30 minutes. NaHCO3 was added and the aqueous phase was extracted with EtOAc 3 times. The combined organic phase was washed with sat aq. ammonium chloride and brine, dried over MgSO4, filtered and evaporated under reduced pressure. The residue was purified by silica gel chromatography affording the title compound, tert-butyl 4-(7-bromo-5-chloro-furo[3,2- b]pyridine-2-carbonyl)-3,3-dimethyl-piperazine-1-carboxylate (295 mg, 0.6240 mmol, 86.26%). ESI-MS m/z calc.471.05606, found 472.24 (M+1)+; Rt: 2.05 min using Method C

259808-67-8, 259808-67-8 1-Boc-3,3-Dimethylpiperazine 22710387, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; SAYEGH, Camil Elie; STURINO, Claudio; FOURNIER, Pierre-Andre; LACOSTE, Jean-Eric; DIETRICH, Evelyne; MARTEL, Julien; VALLEE, Frederic; (494 pag.)WO2016/154075; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

Intermediate B58: 4-[4-(1 -methylethyl)-1 -piperazinyl]-2,5-bis(methyloxy)aniline; Step A/Intermediate B59: 1-[2,5-bis(methyloxy)-4-nitrophenyl]-4-(1- methylethyl)piperazine; 1-chloro-2,5-bis(methyloxy)-4-nitrobenzene (3.25g, 15 mmol, TCI America), isopropylpiperizine (3.84g, 30 mmol, Oakwood Products), cesium carbonate (9.8g, 30 mmol), Pd2dba3 (1.37g, 1.5 mmol), and XANTPHOS (1.3g, 2.25 mmol) were added to degassed dioxane (80 mL) and heated to 1000C under a water cooled reflux condenser for 12 hours. The dioxane was removed under reduced pressure and the solids were partitioned between methylene chloride (500 mL) and water (500 mL). The organic layer was dried over sodium sulfate, taken to a residue under reduced pressure, and purified by chromatography on SiO2 to give 1-[2,5- bis(methyloxy)-4-nitrophenyl]-4-(1-methylethyl)piperazine as a yellow solid (3.5g, 11.3 mmol, 76percent yield). 1 H NMR (400 MHz, CDCI3) delta ppm 1.09 (d, J=6.60 Hz, 6 H), 2.69 – 2.73 (m, 4 H), 2.75 (d, J=6.60 Hz, 1 H), 3.23 – 3.32 (m, 4 H), 3.88 (s, 3 H), 3.94 (s, 3 H), 6.48 (s, 1 H), 7.55 (s, 1 H)., 4318-42-7

The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/20990; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.859518-35-7,tert-Butyl 3-cyanopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

859518-35-7, Step C tert-Butyl 3-cyano-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate A solution of tert-butyl 3-cyanopiperazine-1-carboxylate, prepared as described in the previous step, (10 g, 0.047 mol) and 2-(2-hydroxyethoxy)acetaldehyde (14.8 g) (see: Bodin, A., Contact Dermatitis, 2001, 44:207) in dichloromethane was treated with formic acid (12.7 g), and the reaction mixture was stirred at room temperature overnight. Sodium cyanoborohydride (7.2 g, 0.118 mol) was added in portions. The reaction mixture was stirred at room temperature for 3 hours followed by the addition of water and extraction with dichloromethane. The organic layer was washed with brine, dried over sodium sulfate, filtered, and concentrated. The crude product was purified by column chromatography to provide the product. 1H NMR: (CDCl3, 400 MHz): delta (ppm) 4.15 (s, 1H), 3.69-3.63 (m, 4H), 3.58 (d, J=4.4 Hz, 2H), 3.47-3.44 (m, 4H), 2.61 (d, J=5.2 Hz, 2H), 2.51-2.48 (m, 4H), 1.43 (s, 9H).

859518-35-7 tert-Butyl 3-cyanopiperazine-1-carboxylate 53487922, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Hryhorenko, Eric; Sankaran, Banumathi; DeCory, Thomas R.; Tubbs, Theresa; Colt, Linda; Remmerie, Bart M.; Salter, Rhys; Donahue, Matthew Garrett; Gong, Yong; US2014/57305; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

58077-68-2, 4-(4-Methylpiperazin-1-yl)butanoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

58077-68-2, A solution of (1R,2R)-2-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-[(1H-1,2,4-triazol-1-yl)methyl]propyl 2-(hydroxymethyl)benzoate (1.07 g, 1.58 mmol) obtained from Example 17-(4) in dichloromethane (20 ml) was cooled to 0C, and 4-(N,N-dimethylamino)pyridine (386.1 mg, 3.16 mmol), 4-(4-methyl-1-piperazinyl)butanoic acid (described in J. Med. Chem., 43, 1493 (2000); 529.5 mg, 2.84 mmol), and 1-ethyl-3-[3-(N,N-dimethylamino)propyl]carbodiimide (666.8 mg, 3.48 mmol) were added thereto. The reaction solution was stirred at room temperature for 2 hours, diluted with dichloromethane, and then the organic layer was washed successively with water and a saturated aqueous solution of sodium chloride. The solvent was evaporated under reduced pressure, and the residue was subjected to chromatography on a silica gel (50 g) column (eluent; ethyl acetate : methanol = 4 : 1) to give a mixture of the title target compound and 4-(N,N-dimethylamino)pyridine. The mixture was purified by recycle preparative HPLC [LC-908; Japan Analytical Industry Co., Ltd.; GPC column JAIGEL-1H (20 mm i.d. x 600 mm) and JAIGEL-2H (20 mm i.d. x 600 mm) connected in series for use; solvent, chloroform] to afford the title target compound (901.1 mg, 67% yield) as a colorless amorphous solid. NMR spectrum (400 MHz, CDCl3) delta ppm: 1.46 (3H, dd, J=7, 2 Hz), 1.85 (2H, quint., J=7 Hz), 2.27 (3H, s), 2.3-2.6 (8H, br), 2.37 (2H, t, J=7 Hz), 2.45 (2H, t, J=7 Hz), 3.05 (1H, tt, J=11, 5 Hz), 3.51 (1H, t, J=11 Hz), 3.53 (1H, t, J=11 Hz), 4.01 (1H, q, J=7 Hz), 4.10-4.20 (2H, m), 4.99 (1H, d, J=4 Hz), 5.30-5.56 (4H, m), 5.85 (1H, dd, J=15, 4 Hz), 6.57 (1H, dd, J=15, 10 Hz), 6.73 (1H, d, J=15 Hz), 6.88-7.00 (3H, m), 7.34 (1H, dd, J=10, 1 Hz), 7.37-7.46 (3H, m), 7.52-7.60 (3H, m), 7.79 (1H, d, J=8 Hz), 7.90 (1H, s), 7.95 (1H, s) IR spectrum nu max KBr cm-1: 2230, 1729, 1503, 1357, 1257, 1139, 1051, 973 Mass spectrum m/z (ESI): 845 (M++1) Specific rotation [alpha]D25 -1.8 (c=1.06, CHCl3). A solution of (1R,2R)-2-[[trans-2-[(1E, 3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]-1-(2,4-difluorophenyl)-1-[(1H-1,2,4-triazol-1-yl)methyl]propyl] 2-[[4-(4-methyl-1-piperazinyl)butyryl]oxymethyl]benzoate (290.5 mg, 0.34 mmol) obtained above in ethyl acetate (5 ml) was cooled to 0C, and hydrogen chloride (4N ethyl acetate solution; 86 mul, 0.35 mmol) was added thereto, and then the mixture was stirred at 0C for 5 minutes. The solvent was distilled off under reduced pressure to afford the mono hydrochloric acid salt of the title compound (305.1 mg, quantitative yield) as a pale yellow amorphous solid. NMR spectrum (400 MHz, CDCl3) delta ppm: 1.46 (3H, dd, J=7, 2 Hz), 1.90 (2H, br), 2.47 (2H, t, J=7 Hz), 2.6-2.8 (13H, br d), 3.05 (1H, tt, J=11, 5 Hz), 3.51 (1H, t, J=11 Hz), 3.53 (1H, t, J=11 Hz), 4.01 (1H, q, J=7 Hz), 4.10-4.15 (1H, m), 4.18 (1H, ddd, J=11, 5, 2 Hz), 4.99 (1H, d, J=4 Hz), 5.44 (1H, d, J=14 Hz), 5.46-5.53 (2H, m), 5.55 (1H, d, J=15 Hz), 5.85 (1H, dd, J=15, 4 Hz), 6.57 (1H, dd, J=15, 11 Hz), 6.74 (1H, d, J=15 Hz), 6.89-6.93 (2H, m), 6.94 (1H, dd, J=15, 11 Hz), 7.34 (1H, dd, J=10, 1 Hz), 7.40-7.47 (3H, m), 7.54-7.62 (3H, m), 7.84 (1H, d, J=7 Hz), 7.89 (1H, s), 7.97 (1H, s) IR spectrum nu max KBr cm-1: 2230, 1729, 1503, 1274, 1256, 1139, 1051, 973 Mass spectrum m/z (ESI): 845 [M(free base)++1] Specific rotation [alpha]D25 -4.5 (c=0.89, CHCl3)

The synthetic route of 58077-68-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sankyo Company, Limited; EP1362856; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4318-42-7

(1H-Indol-5-yl)-(4-isopropyl-piperazin-1-yl)-methanone A mixture of 3.23 g (20 mmol) indole-5-caboxylic acid (commercially available), 3.07 g (24 mmol) 1-(2-propyl)-piperazine (commercially available), 8.03 g (25 mmol) TBTU and 10.3 mL (60 mmol) DIPEA in 50 mL DMF was stirred for 2 h (hours) at room temperature. After evaporation of all volatiles the residue was extracted with ethyl acetate, the combined organic layers dried with MgSO4 and evaporated to dryness. The residue was subsequently purified by flash column chromatography eluding with a mixture formed from DCM, MeOH, and NH3 aq. to yield after evaporation of the combined product fractions 5.1 g (94percent) of the title compound as light brown foam. MS(m/e): 272.3 (MH+).

The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nettekoven, Matthias Heinrich; Roche, Olivier; US2007/270423; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

692058-21-2, 1-Boc-4-(2,2,2-trifluoroethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,692058-21-2

tert-butyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate (253 mg, 0.94 mmol) was dissolve in DCM (9 mL) and a solution of 4 M HCI in dioxane (4.72 mL, 18.9 mmol) was added. The reaction was stirred 3 h at rt. The product was then concentrated in vacuum and co evaporated with DCM 3 times, affording the title compound (200 mg, 0.977 mmol, 100%) as beige solid.

As the paragraph descriping shows that 692058-21-2 is playing an increasingly important role.

Reference£º
Patent; BANTAM PHARMACEUTICAL, LLC; SIDDIQUI, Arshad, M.; CIBLAT, Stephane; DERY, Martin; CONSTANTINEUA-FORGET, Lea; GRAND-MAITRE, Chantal; BRUNEAU-LATOUR, Nicolas; SHIPPS, Gerald, W.; COOPER, Alan, B.; OZA, Vibha; KOSTURA, Matthew, W.; LUTHER, Michael; LEVINE, Jedd; (174 pag.)WO2018/102453; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55276-43-2,1-Methanesulfonylpiperazine,as a common compound, the synthetic route is as follows.

55276-43-2, Examples of the Good’s buffer include, but are not limited to, N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), 2-morpholinoethanesulfonic acid (MES), N-(2-acetamide) iminodiacetic acid (ADA), piperazine-N,N’-bis(2-ethanesulfonic acid) (PIPES), N-(2-acetamide)-2-aminoethanesulfonic acid (ACES), 3-morpholino-2-hydroxypropanesulfonic acid (MOPSO), 3-morpholinopropanesulfonic acid (MOPS), N-[tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid (TES), 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (HEPES), …

As the paragraph descriping shows that 55276-43-2 is playing an increasingly important role.

Reference£º
Patent; Arkray, Inc.; EP2380593; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics