Month: November 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

tert-Butyl4-(4-(6-chloro-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H- imidazo[4,5-?>]pyridin-2-yl)phenyl)piperazine-1-carboxylateTo a mixture of 5-chloro-4-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3- nitropyridin-2-amine (0.100 g, 0.27 mmol, 1 eq), EtOH (4.7 mL) and DMF (0.63 mL), terf-butyl-4-(4-formylphenyl)tetrahydro-1-(2H)pyrazine carboxylate (0.087 g, 0.3 mmol, 1.1 eq) was added followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.82 mL, 0.82 mmol). The reaction mixture was heated at 85C for 24 h, then allowed to cool to room temperature and diluted with DCM and a few drops of aqueous NH3 until complete dissolution was observed. This solution was deposited on two preparative silica TLC plates and eluted with DCM/MeOH (v/v; 94:6). The title compound was obtained after trituration with diethyl ether as an off-white solid (0.050 g, 30%); 1H-NMR (500Mz, DMSO-c/6): delta 1.43 (s, 9H, C(CH3J3), 2.59-2.67 (m, 4H, piperazine N(CH2)2), 3.45-3.52 (m, 4H, piperazine N(CH2J2), 3.66 (s, 2H, NCH2), 3.65-3.74 (m, 4H, piperazine N(CH2)2), missing 4H piperazine N(CH2)2 under solvents peaks, 7.07 (d, J = 9.5 Hz, 2H, ArH, C6H4), 7.64-7.74 (m, 1 H, py 4-H)1 8.01- 8.07 (m, 3H, ArH and imidazo [4,5-]pyridine 5-H), 8.44-8.47 (m, 1 H), 8.49 (d, J = 2.5 Hz, 1H, py 6-H), 13.19 (br s, 1H, imidazo[4,5-b]pyridine N-H); LC (Method B) – MS (ESI, m/z) 4.51 min – 607/609 [(M+H)+, Cl isotopic pattern]; ESI-HRMS: Found: 607.2743, calculated for C31H36CIFN8O2 (M+H)+: 607.2707.

197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.

Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

The 20 mmol 4, 6 – dichloro -2 – methyl pyrimidine, 35 mmol K3 PO4 Dissolved in 16 mmol 1 – butyl -3 – methyl imidazole glycine salt and stirring, adding 21 mmol N – hydroxyethyl piperazine, for 80 C reaction under 1.5 h after, cooling to room temperature, add-on enters 21 mmol2 – amino – N – (2 – chloro -6 – methyl phenyl) -5 – thiazole carboxamide, for 80 C continues reaction under 2 h, after the reaction, cooling to room temperature, the mixture extracted with ethyl ether 3 times (3 ¡Á 50 ml), the combined extraction liquid and concentrated, get the crude product (ionic liquid to the methylene chloride extraction, vacuum drying in order to remove the small amount of solvent, the residual viscous ionic liquid ethyl ether after being sufficiently washed directly used for the next reaction, without further purification). The crude product by adding 80% ethanol aqueous solution 100 ml, under stirring, by adding 2 g of activated carbon, reflux 30 min, is still hot filtration, filtrate refrigeration crystallization overnight, filtered, the filter cake of ice 80% ethanol aqueous solution washing, drying, to obtain white solid 9.01 g, yield 92.27%, purity of 99.94%., 103-76-4

As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Gao Hongjun; Zhang Hui; Ren Qingwei; (13 pag.)CN109503568; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of tetrahydro-pyran-4-carboxylic acid (0.477 g, 2.27 mmol, 1.0 eq. ) EDCA (0.480 g, 2.50 mmol, 1.1 eq. ) and HOBt (0. 340 g, 2. 50 mmol, 1.1 eq. ) in THF/DMF (8 mL/2 mL) is kept under magnetic stirring at room temperature for about I hour. PIPERAZINE-L-CARBOXYLIC acid benzyl ester (0.438 mL, 2.27 mmol, 1. 0 eq. ) is then added and the resulting reaction mixture is left to react for 14 hours. AcOEt (10 mL) and a 10percent solution OF NAHCO3 (10 mL) are added and the phases are separated. The organic phase is then washed with water (2×10 mL) and brine (10 mL), dried on N2aSO4, filtered and the solvent removed by evaporation under reduced pressure. 4-(Tetrahydr-pyran-4-carbonyl)- piperazine-1-carboxylic acid benzyl ester (32) is obtained as an ivory coloured solid (0. 613 g, I. 85 mmol, yield = 81percent) which does not require further purification. HPLC (method A): Rt=7.71 min., 31166-44-6

The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MENARINI RICERCHE S.P.A.; WO2004/94412; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the product of Step 4 (10.0 g, 50.0 mmol) in anhydrous DMF(250 ml) in an ice-water bath were added sodium hydride (2.40 g, 60.0 mmol) andbenzyl chloride (6.60 g, 52.5 mmol). The mixture was stirred at RT for 4.5 h. Thereaction was quenched with water (10 ml), diluted with CH2CI2 (500 ml), and washed with water (2x250ml). The organic layer was extracted with saturated NH4CI (200 ml),dried (MgSO4), concentrated, and purified by column chromatography (gradientMeOH/CH2CI2 0-5%) to give the product (10.7 g, 74%). 1H-NMR (CDCI3): 6=7.2-7.3(m, 5H), 4.57 (s, 2H), 4.10 (s, 2H), 3.53 (m, 2H), 3.19 (m, 2H), 1.41 (s, 9H), 76003-29-7

76003-29-7 1-Boc-3-Oxopiperazine 3157178, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING CORPORATION; WO2006/14762; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

75336-86-6, To a 0 0C solution of (R)-2- methylpiperazine (5.0 g, 50 mmol, 1.0 equiv) in dry DCM (200 mL) was added triethylamine (21 mL, 150 mmol, 3 equiv) by syringe. A solution of BOC2O (10.4 g, 47.4 mmol, 0.95 equiv) was then added as a solution in dry DCM (100 mL) over the course of an hour. After stirring for an addition 15 min at 0 “C, the reaction mixture was stirred at room temperature for 30 min. The reaction mixture was then washed with aq. satd. NaHCO3 and brine. The resulting DCM solution was dried over sodium sulfate, filtered, and concentrated in vacuo, and used in the next step without further purification. The residue was dissolved in dry DCM (50 mL), and Et3N (21 mL, 150 mmol, 3 equiv) was added by syringe. To this room temperature solution was added CbzCI (8.4 mL, (>0 mmol, 1.2 equiv) dropwise by syringe. After stirring at room temperature for 30 minutes, the mixture was quenched by the addition of aq. satd. NaHCC<3. The solution was washed an additional time with aq. satd. NaHCO3, twice with aq. 1 N KHSO4, and twice with brine. The DCM layer was dried over sodium sulfate, filtered, and concentrated in vacuo. The resulting residue was dissolved in MeOH (100 mL), and HCl (4 N in dioxane, 150 mL, 600 mmol, 12 equiv) was added dropwise by syringe. After 2 h, the reaction mixture was concentrated in vacuo. To the resulting solid was added EtOAc and 1 N NaOH. The aqueous layer was extracted twice with EtOAc, and the organic layers were combined and washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo to provide (/?)-benzyl 2-methylpiperazine-l-carboxylate (5.3 g, 45%). 75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields. Reference£º
Patent; CYTOKINETICS, INC.; WO2007/70683; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

[3-DICHLOROPYRIDINE] (2.94 [G, 20.] 0 [MMOL),] [(R)-2-METHYLPIPERAZINE] (2.75 g, 27.5 mmol) (Commercially available from [SIGMA-ALDRICH,] St. Louis, [MO] (www. sigma- [ALDRICH.] [COM)),] and triethylamine (3. [04] g, 30 mmol) were dissolved in 15 mL of dimethylsulfoxide and the resulting mixture was heated at about [100C FOR ABOUT] 24 [ H. THE] reaction mixture was then cooled to room temperature and extracted with a saturated aqueous sodium bicarbonate solution. The organic layer was dried, concentrated, and purified using a silica gel column eluted with a gradient elution (ethyl acetate to [2 : 1 ETHYL ] acetate : methanol) to provide Compound 1 [(N- (3-CHLOROPYRIDIN-2-YL)-PIPERAZINE) AS] a yellow liquid (90percent yield).

75336-86-6, 75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; EURO-CELTQUE, S.A.; WO2004/29031; (2004); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 17 3-Methyl-5-[2-[4-[4-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2-oxazolidinone This compound was prepared according to the procedure of Example 2. A mixture of 3.5 g (0.015 mol) of 1-(4-trifluoromethylphenyl)piperazine (Emka-Chemie), 2.5 g (0.015 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 5.3 g (0.05 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol gave 3.7 g (69%) of white solid, mp 116-117 C. (2-propanol). Anal. Calculated for C17 H22 F3 N3 O2: C, 57.14; H, 6.20; N, 11.76. Found: C, 56.74; H, 6.24; N, 11.55., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; A. H. Robins Company, Incorporated; US5086055; (1992); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.

To a stirred solution of 1 -(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene (step 1 intermediate) (4.0 g, 14.1 mmol) in dichloromethane (40 mL) were added N-ethylpiperazine(1.88 mL, 14.7 mmol) followed by N,N-diisopropylethylamine (DIPEA) (3.27 mL, 19.1 mmol) at RT. The mixture stirred at RT for 16 h. The reaction mixture was diluted with dichloromethane and washed with saturated sodium bicarbonate solution followed by brine. The organic layer was dried over anhydrous sodium, filtered and concentrated under reduced pressure. The residue obtained was purified by column chromatography to yield 3.5 g of thedesired product. ?H NMR (400 MHz, DMSO-d6) oe 0.96 (t, J = 7.2 Hz, 3H), 2.28-2.5 1 (m,1OH), 3.72 (s, 2H), 8.09 (d, J= 8.4 Hz, 1H), 8.40 (s, 1H), 8.51 (dd, J, = 2.4 Hz, J2 = 8.8 Hz,1H)., 5308-25-8

As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; PATEL, Vinod; REDDY, Venkateshwar; GHARAT, Laxmikant Atmaram; CHAUDHARI, Sachin Sundarlal; DAS, Sanjib; VELGALETI, Ranganadh; SHAH, Daisy Manish; BAJPAI, Malini; (262 pag.)WO2018/215668; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

67455-41-8, Example No. 188Preparation of N- (3- (7- ( (4- (piperazin-l-yl) phenyl) amino) -1H- pyrazolo [4, 3-d] pyrimidin- 5 -yl) phenyl) methanesulfonamideN- (3- (7-chloro-2- (4-methoxybenzyl) -2H-pyrazolo [4,3- d] pyrimidin- 5 -yl) phenyl) methanesulfonamide (0.16 mmol) and 4-(piperazin-l-yl) aniline (0.3 mmol 2 eq. , ) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HCl in dioxane(4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was concentrated and purified by semi- preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 464.2094 g/molHPLC-MS: analytical method Lrt: 2.90 min – found mass: 465 (m/z+H)

67455-41-8 4-(Piperazin-1-yl)aniline 422925, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; TRAUBE, Nadine; WO2012/143144; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(i) tert-Butyl 4-(2-(5-(tert-butyl)-2-methoxy-3-(3-(4-((2-(phenylamino)pyridin-4-yl)oxy)- naphthalen-1-yl)ureido)benzamido)ethyl)piperazine-1-carboxylateA stirred mixture of 5-(tert-butyl)-2-methoxy-3-(3-(4-((2-(phenylamino)pyridin-4- yl)oxy)naphthalen-1-yl)ureido)benzoic acid, HCI (see Example 14(iii) above; 80 mg, 0.130 mmol), tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate (59.8 mg, 0.261 mmol) and triethylamine (72.7 muIota_, 0.522 mmol) in DCM (4 mL) was cooled in an ice-bath. 50 wtpercent T3P in EtOAc (93 muIota_, 0.157 mmol) was added, the ice-bath was removed and the reaction mixture allowed to warm to rt and stirred for 36 h. The reaction mixture was partitioned between sat. aq. NaHCC>3 (10 mL) and DCM (10 mL). The aqueous phase was back extracted with fresh DCM (10 mL). The combined organic extracts were washed with water (20 mL), brine (20 mL), dried (MgSC ), filtered and concentrated in vacuo onto silica gel. The crude product was purified by chromatography on the Companion (12 g column, 1-5percent MeOH in DCM) to afford the sub-title compound (52 mg) as a pink/brown solid.LCMS m/z 788 (M+H)+(ES+); 786 (M-H)”(ES”)

192130-34-0, The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics