5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5308-25-8
Add to the reaction flask5-bromo-2-nitropyridine (4.0 g, 19.7 mmol), 1-ethylpiperazine (3.4 g, 29.8 mmol)K2CO3 (4.1 g, 29.6 mmol), TBAI (0.42 g, 1.2 mmol) and dimethylsulfoxide (40 mL) were added and the mixture was heated with stirring at 80 C for 16 hours.The mixture was cooled to room temperature and the reaction solution was poured into ice water and extracted with dichloromethane (20 mL x 3).The combined organic layers were washed with saturated brine (20 mL), dried over anhydrous sodium sulfate,The filtrate was concentrated in vacuo. The residue was purified by column chromatography (DCM / MeOH = 10: 1)The resulting residue was purified to give the title compound (3.59 g, brown solid) in 77% yield.
The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
Piperazine – Wikipedia
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