548762-66-9, (2S,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 214 mg (1 mmol) tert-butyl (2S,5R)-2,5-dimethylpiperazine-1- carboxylate in 3.3 mL THF were added at RT 1.74 mL DIPEA (10 mmol, 10 eq) and 194 mg 3- fluorobenzenesulfonyl chloride (1 mmol, 1 eq) and the mixture was stirred for 3 days at RT. The mixture was evaporated to yield 496 mg (133%) of the crude title compound which was used in the next step without further purification. (0532) LC-MS (Method 1): Rt = 1.33 min; MS (ESIpos): m/z = 373 [M+H]+ (0533) 1H-NMR (500 MHz, DMSO-d6) delta [ppm]: 0.84 (3H), 0.99 (3H), 1.38 (9H), 3.09 – 3.19 (3H), 3.54 – 3.67 (3H), 4.03 – 4.31 (2H), 7.56 (1 H), 7.61 – 7.72 (3H)., 548762-66-9
548762-66-9 (2S,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate 11745988, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; SIEBENEICHER, Holger; STEUBER, Holger; TER LAAK, Antonius; NUBBEMEYER, Reinhard; ROTTMANN, Antje; IRLBACHER, Horst; BADER, Benjamin; PETERS, Michaele; WAGENFELD, Andrea; (157 pag.)WO2018/114670; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics