With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Adding ZTH-1 (10.7g, 50mmol, 1eq) into 250ml flask; adding 100ml tetrahydrofuran, kalium carbonicum (10.35g,75mmol, 1.5eq) and methyl iodide (8.52g, 60mmol, 1.2eq) in turn; reacting under room temperature overnight; filteringand condensing, adding 100ml water and 100ml dichloromethane into the residue; and rinsing with dichloromethane(50ml x twice), merging organic layer, rinsing with saturated brine, drying with anhydrous sodium sulfate, condensing,and column chromatography of the residue (methanol : dichloromethane = 1:20), 5.7g orange-colored oily substance ZTH-2 is obtained, wherein the yield is 50%.
129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Suzhou Maidixian Pharmaceutical Inc.; Zhang, Nan; Zhong, Rong; ZHANG, Nan; ZHONG, Rong; EP2589601; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics