208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Take 1.86g of 4-hydroxybenzaldehyde and 3.72g of intermediate A22 in a 50ml round bottom flask was added 15mlN, N- dimethylformamide, another additional 4.2g of potassium carbonate, the reaction solution in a 85 C oil bath Stirred for 3 hours, cooled to room temperature. The reaction mixture was diluted with ethyl acetate and washed with water four times. The ethyl acetate layer was separated and dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure. The residue was chromatographed on silica gel with petroleum ether-ethyl acetate = 4: 1, petroleum ether-ethyl acetate = 1: 1, then with petroleum ether-ethyl acetate = 1: 1 and 1% by volume of triethylamine Column chromatographyTo give 3.35 g of intermediate A23 in a yield of 66%, 208167-83-3
208167-83-3 tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate 22106269, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Tsinghua University; Rao Yu; Wu Wei; Lan Tianlong; Hu Jiantao; Fan Zhongyun; Huang Binlu; (31 pag.)CN107286098; (2017); A;,
Piperazine – Wikipedia
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