With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.325145-35-5,(S)-tert-Butyl 2-ethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
The 3 – ((2,4-dioxo -3,4-dihydrochinazolines having antiviral properties -1 (2H)-yl) methyl) benzoic acid (150 mg, 0 . 51mmol), HATU (388 mg, 1 . 02mmol), HOBt (138 mg, 1 . 02mmol) and TEA (104 mg, 1 . 02mmol) into the reaction bottle in, addition of about 5 ml of the dissolution of water-free DMF, r.t. The lower stirring 15 min, then dropwise (S)-N-Boc-2-ethyl piperazine (153 mg, 0 . 76mmol) in the DMF solution to the reaction solution, r.t. The lower stirring sleepovers, reducing pressure and evaporating solvent, addition of about 20mLDCM, saturated NaHCO3washing (25 ml ¡Á 2), dried anhydrous sodium sulfate, silica gel column chromatography to obtain 150 mg of solid, yield 65.8percent.
325145-35-5, As the paragraph descriping shows that 325145-35-5 is playing an increasingly important role.
Reference£º
Patent; Institute Of Materia Medica Chinese Academy Of Medical Sciences; Xu, Bailing; Chen, Xiaoguang; Yao, Haiping; Ji, Ming; Jin, Jing; Zhou, Jie; Wang, Ke; Zhao, Dalong; (55 pag.)CN105461697; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics