630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,630125-91-6
To a solution of 2-chloro-4 6-dimethylpyrimidin-5-amine (50 mg 0.317 mmol) in THF (10 mL) was added triphosgene (33.0 mg 0.111 mmol) . The resulting mixture was stirred at 70 . After LCMS analysis showed the starting material was disappeared. The solvent was removed in vacuo to give 2-chloro-5-isocyanato-4 6-dimethylpyrimidine (50 mg 0.257 mmol 81yield) . To a solution of 4- ( (4-ethylpiperazin-1-yl) methyl) -3- (trifluoromethyl) aniline (94 mg 0.327 mmol) and Et3N (0.114 mL 0.817 mmol) in THF (10 mL) was added a solution of 2-chloro-5-isocyanato-4 6-dimethylpyrimidine (50 mg 0.272 mmol) in THF (10 mL) . The resulting mixture was stirred at 70 . After LCMS analysis showed the starting material was disappeared. The solvent was removed in vacuo. The residue was dissolved in DCM (60 mL) and washed with H2O (20 mL) and brine (20 mL) . The organic layer was dried over Na2SO4 filtered and concentrated. The residue was purified by preparative HPLC (DCM/MeOH 10/1) to yield a white solid of 1- (2-chloro-4 6-dimethylpyrimidin-5-yl) -3- (4- ( (4-ethylpiperazin-1-yl) methyl) -3- (trifluoromethyl) phenyl) urea (80 mg 0.167 mmol 61.2yield) 1HNMR(400 MHz CD3OD) delta 7.88 (s 1H) 7.39 (d J 8.0 Hz 1H) 6.99 (d J 2.8 Hz 1H) 3.75 (s 2H) 3.04 (m 8H) 2.49 (m 8H) 1.37 (m 3H) ES-LCMS m/z 471.0 (M+H)
630125-91-6 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 59134564, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Piperazine – Wikipedia
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