With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-86-3,(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of the free carboxylic acid (1 equiv.) in dry dichloromethane (0.05 M solution) (S)-lambdaM -Boc-2-benzylpiperazine (1.05 equiv.), EDCI (1.1 equiv.), HOBt (1.1 equiv.) and DIPEA (2 equiv.) were added at room temperature. The reaction was stirred overnight, the solvent evaporated under reduced pressure and the crude material purified by flash chromatography.; (S)-fert-butyl-2-benzyl-4-[5-/so-butyl-6-(3-/so-butyl-1W-pyrazol-5- yl)pyridazine-3-carbonyl]piperazine-1-carboxylate 12b: Rf = 0.21 (CH2CI2/Me0H = 98:2)., 169447-86-3
169447-86-3 (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate 17750441, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/25751; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics