With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.
13484-40-7, Preparation of 2-Chloro-6-[4-(2-methoxy-ethyI)-piperazin-l-yl]-pyrimidine-4- carboxylic acid methyl ester:; To a solution of 2,6-dichloro-pyrimidine-4-carboxylic acid methyl ester (580 mg, 2.8 mmol) in DCM (6 mL) at 0 C was added triethylamine (0.39 mL, 2.8 mmol), followed by a solution of l-(2-methoxyethyl)piperazine (406 mg, 2.8 mmol) in DCM (6 mL). The resulting solution was stirred at 0 C for 30 min. The reaction mixture was diluted with water and extracted with DCM (3×80 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated to afford 870 mg (99%) of the title compound as a pale yellow solid.
13484-40-7 1-(2-Methoxyethyl)piperazine 2734638, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; SIRTRIS PHARMACEUTICALS, INC.; WO2009/61453; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics