25057-77-6, 1,2-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 65: tert-butyl (1 S)-1 -(4-((3,4-dimethylpiperazin-1- yl)methyl)phenyl)ethyl carbamateA solution of (S)-tert-butyl 1 -(4-formylphenyl)ethylcarbamate (84.1 mg, 0.337 mmol) [obtained from (S)-1-(4-bromophenyl)ethanamine following the procedure of Hashihayata, Takashi PCT Int. Appl., 2008081910, 10 Jul 2008] and 1 ,2- dimethylpiperazine (86.3 mg, 0.756 mmol, 2.24 equiv) in THF (1.5 mL) was stirred at room temperature for 65 min and treated with sodium triacetoxyborohydride (277.2 mg, 1 .308 mmol, 3.88 equiv). The resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was quenched with saturated aqueous solution of NaHCO-3(15 mL) and extracted with EtOAc (5 x 15 mL). Combined organics were dried over Na2S04, filtered and concentrated. Silica gel column chromatography (MeOH/CH2Cl2 0 to 20%) provided tert-butyl (1 S)-1 -(4-((3,4-dimethylpiperazin-1-yl)methyl)phenyl)ethyl carbamate (90.7 mg) in 34.5% yield. 1 H NMR (400 MHz, CD3OD) delta 7.29 (s, 4 H), 4.68 (br s, 1 H), 3.54 – 3.47 (m, 2 H), 3.37 (s, 1 H), 2.84 – 2.74 (m, 3 H), 2.38 (td, J = 12, 2.5 Hz, 1 H), 2.31 (s, 3 H), 2.28 – 2.22 (m, 2 H), 1.94 – 1.89 (m, 1 H), 1.40 (br s, 9 H), 1.38 (d, J = 6.9 Hz, 3 H), 1 .06 (d, J = 6.3 Hz, 3 H); MS m/z 348.2 (M + H)
25057-77-6, As the paragraph descriping shows that 25057-77-6 is playing an increasingly important role.
Reference£º
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; TOURE, Bakary-Barry; YANG, Fan; CAFERRO, Thomas; LEI, Huangshu; LENOIR, Francois; LIU, Gang; PALERMO, Mark G.; SHULTZ, Michael David; SMITH, Troy; COSTALES, Abran Q.; PFISTER, Keith Bruce; SENDZIK, Martin; SHAFER, Cynthia; SUTTON, James; ZHAO, Qian; WO2013/46136; (2013); A1;,
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