With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.,59878-57-8
To a solution of 1 i (28 mg, 0.089 mmol) in acetonitrile (2 mL) were added DIPEA (48 muIota_, 0.267 mmol), 1j (15 muIota_, 0.107 mmol) and HATU (41 mg, 0.107 mmol). The resulting mixture was stirred at room temperature for 2 h and purified by reversed phase prep HPLC to give title compound 1 as white solid (36 mg, 90% yield). The mass of the compound was obtained by Shimadzu LCMS-2020, MS(ESI) : m/z = 451 [M+H]
The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ETERNITY BIOSCIENCE INC.; LIU, Dong; ZHANG, Minsheng; HE, Kan; ZHANG, Lianshan; WO2012/125521; (2012); A1;,
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