With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5
To a solution of EXAMPLE 26B (74 mg, 0.15 mmol) in dichloromethane (10 mL) was added 2-(4-methylpiperazin-l -yl)ethanamine (11 1 mg, 0.78 mmol), 2-(7-aza-lH- benzotriazole-l -yl)-l, l ,3,3-tetramethyluronium (1 18 mg, 0.312 mmol) and triethylamine (79 mg, 0.78 mmol). After stirring at ambient temperature for 2 hours, the mixture was poured into water (30 mL) and extracted with dichloromethane (30 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered, concentrated and purified by preparative HPLC using a gradient of 10/90 to 90/10 acetronitrile in water (containing 0.1 percent trifluoroacetic acid) to give the title compound. NMR (DMSO-ak, 300 MHz): delta ppm 12.29 (s, 1 H), 1 1.60 (s, 1 H), 8.35 – 8.31 (m, 2 H), 7.58 (d, J = 8.1 Hz, 2 H), 7.42 – 7.38 (m, 3 H), 7.20 (d, J = 8.7 Hz, 1 H), 6.84 (s, 1 H), 6.47 (d, ./ = 7.5 Hz, 1 H), 4.44 (s, 2 H), 3.93 (s, 3 H), 3.00 (s, 3 H), 2.55 (bra, 12 H). MS 595.2 (M + H ).
The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97683; (2012); A1;,
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