With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.,5308-25-8
At Step 1, obtained 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine 80.0 g was in the dimethylformamide 560 ml and the temperature was raised to 70C after the input and the ethylpiperazine 47.29 g and diisopropylethylamine 46.38 g were reacted for 5 hours. The temperature of this reaction solution was cooled to the room temperature and the purified water 560ml was cooled after doing injection to 10C . Here, the generated Decision was filtered to the Nutsche filtration (Buchner funnel, Coors) and the residue was washed with the purified water 250 ml. This Decision was recrystallized as ethanol and it dried in 70C and the white blonanserin 100 g (yield 98.6 %) was obtained.
5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; SAM-OH PHARMACEUTICAL CO., LTD.; KIM, DAE SIK; HO, CHEOL; (6 pag.)KR2015/117123; (2015); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics