With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.
5308-25-8, 8.9 ml of ethylpiperazine are placed in 91.5 ml of toluene in a round-bottomed flask. A solution of 4.1 ml of ethyl bromoacetate in 11.6 ml of toluene is added dropwise. The mixture is refluxed at 110 C. for one hour, concentrated to a small volume and left in a refrigerator for 3 hours. A white precipitate forms, which is filtered off and washed with dichloromethane. The filtration liquors are evaporated; 7 g of expected product are obtained.
5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; SANOFI-AVENTIS; US2010/210662; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics