With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
A suspension of IX-214 (30 mg; 0.065 mmol; Example 1), potassium carbonate (9 mg; 0.065 mmol) and potassium iodide (2 mg; 0.012 mmol) in ethanol (1 mL) was stirred 5 min at room temperature, was supplemented with /-butyl 4-(2-chloroethyl)piperazine-l-carboxylate (24.3 mg; 0.098 mmol; Acros Organics), and was stirred 6 h at 80C. The reaction mixture was evaporated, re-dissolved in 10 mL water, and extracted with dichloromethane (3 x 10 mL). The pooled extracts were dried over anhydrous sodium sulfate, filtered, and evaporated, and the product was purified by silica chromatography (methanol/di chloromethane gradient).Yield: 34.4 mg; 79%., 208167-83-3
The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; EBRIGHT, Richard H.; EBRIGHT, Yon W.; LIN, Chih-Tsung; (85 pag.)WO2019/226915; (2019); A1;,
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