120737-59-9, tert-Butyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution OF 3-METHYL-PIPERAZINE-L-CARBOXYLIC acid tert-butyl ester (1.0 g, 5.3 mmol) and OF L-BROMO-4-TRIFLUOROMETHYL-BENZENE (1.0 g, 4.4 mmol) in toluene (10 ml) were added sodium-tert butylate (0.6 g, 6.2 mmol), 2- (DICYCLOHEXYLPHOSPHINO) biphenyl (31 mg, 89 mmol), and tris (dibenzylideneacetone) dipalladium-chloroform complex (23 mg, 22 mmol). The reaction mixture was then stirred for 16 hours at 80 ¡ãC. After allowing to cool to room temperature the reaction mixture was concentrated IN VACUO and purified by column chromatography (Si02, 70g, heptane/ethyl acetate 0-30percent) to give the title compound as a light brown solid (0.47 g, 31 percent). MS (m/e): 345.2 (M+HT, 100percent).
120737-59-9, The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/23260; (2005); A1;,
Piperazine – Wikipedia
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